Our Goal
The Rosetta Commons aims to develop high resolution protein prediction and design software. The Commons provides an environment for continuous sharing and collaborative development of the Rosetta software platform. The Commons facilitates interaction among participating institutions and researchers and makes the Rosetta software broadly available to the scientific community.
Software
The Rosetta software suite focuses on the prediction and design of protein structures, protein folding mechanisms, and protein-protein interactions. Rosetta has been consistently successful in CASP and CAPRI competitions. Rosetta also addresses aspects of protein design, docking and structure. The software is the foundation for the Human Proteome Folding Project on the World Community Grid and the Roseta@home distributed computing project.
Software Availability
The Rosetta software suite is currently licensed for free to users at academic and nonprofit institutions. Over 2000 academic users in more than 32 countries use Rosetta. Commercial entities can use Rosetta by paying a license fee. Revenue from licensing is reinvested in supporting continued software development.
Our Research
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Structures of designed enzymes. Jiang L, et al(2008).De novo computational design of retro-aldol enzymes.Science 319, 1387-91. |
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1.6 Å C{alpha}-RMSD blind structure prediction for CASP6 target T0281, hypothetical protein from Thermus thermophilus Hb8.(Bradley P, Misura KM, Baker D, Science. 2005 Sep 16;309(5742):1868-71.) |
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Ribbon diagrams of Top7 with residues 46 to 76 highlighted in red -- A novel protein structure created with RosettaDesign.(Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D, Science 302, 1364-8.) |