Meiler Lab (Vanderbilt)
The Meiler laboratory at Vanderbilt University in Nashville, Tennessee has openings for post-doctoral fellows interested in the development and application of RosettaLigand and RosettaMembrane. Specifically we develop a structure-based drug design module for Rosetta, test novel approaches for ligand docking into membrane protein targets, design proteins to bind small molecules, and determine protein structures from sparse/low resolution experimental data. Qualified applicants should have a PhD in Biology, Chemistry, Math, Physics or Computer Science. In addition the individual should have two years of experience in one or multiple of the following areas: computational biology or chemistry, mathematics, physics, software engineering/development, web application development, object oriented programming, or SQL database design.
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An NSF-funded postdoctoral position is available under the supervision of Professors Jeffrey Gray and Marc Ostermeier in the Department of Chemical and Biomolecular Engineering at Johns Hopkins University, Baltimore, MD.
Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center’s four scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Children’s Hospital and Regional Medical Center, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference.
A post-doctoral position is available in the Kortemme Lab to join our efforts in computational design of protein-based small molecule biosensors. The post-doctoral researcher will work closely with our computational design group to develop and apply methods to engineer novel functional protein interfaces, in particular utilizing newly developed methods for flexible backbone modeling (see Nature Methods 6:551, 2009 and Nature Chemical Biology 5:797, 2009). We are seeking a highly motivated, rigorous experimentalist with strong publications in international journals. Qualified candidates should expect or hold a Ph.D. in biochemistry, biophysics, molecular biology or a related area.
A postdoctoral position is available in the laboratory of Brian Kuhlman in the Department of Biochemistry and Biophysics at the University of North Carolina Chapel Hill. The goal of the project is to explore the use of non-natural amino acids in Rosetta for protein design. In particular, we are interested in using amino acids with novel shapes and hydrogen bond capabilities to modulate the stability and activity of proteins and protein complexes. Qualified candidates should have a PhD in chemistry, biochemistry, or similar fields and have experience in molecular modeling.