I am trying to run the ddg_monomer high-res protocol on a protein. I am running this on a Linux system with 4 GB of RAM. Immediately after the protocol begins to run, RAM usage gets very high and my computer freezes. It remains frozen indefinetely. Is this normal? Usually when I run other ROSETTA protocols, the computer is perfectly usable with the job running in the background.
I am using all the default settings from the high-res protocol (row 16 of Kellogg et al) from the documentation: