The confussion about an example in tutorial in Rosetta Virtual Workshop 2020
Submitted by ldx022 on Tue, 2022-11-29 04:58
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Design
Adding NCAA with Metal Ion
Submitted by MustafaBughio on Mon, 2022-11-28 15:07
Category:
Design
Hi
I am writing here after so much struggle with incorporation of NCAA (Bpy-Ala) using different rosetta scripts like:
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Error in rosetta_scripts.mpi.linuxgccrelease: double free or corruption (!prev): 0x0000000007697a90
Submitted by almeida85 on Thu, 2022-11-17 01:04
Category:
Design
Hello,
I am running a xml script with rosetta_scripts (Rosetta 3.14, v2022.11) in my HPC cluster and I am getting the following error:
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hpatch IG bug and fix
Submitted by rjacak on Mon, 2022-10-17 08:24
Category:
Design
Hi Rocco, Steven, et al,
Posting this here since it appears that the Rosetta bugs reporting tool is currently down.
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GeneralizedKIC side chain closure.
Submitted by almeida85 on Mon, 2022-09-19 06:13
Category:
Design
Hi all,
I want to generate cyclic peptides in a binding site employing the anchor design approach similar to https://www.nature.com/articles/s41467-021-23609-8 and https://www.pnas.org/doi/suppl/10.1073/pnas.2012800118. I need to do the closure by amidation between two side chains (K/E) or side chain/C-terminal.
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Rosettascript - change residue number and chain ID
Submitted by cttm4a1 on Wed, 2022-09-14 23:40
Category:
Design
I was trying to use Rosettascript to perform a grafting task. I found that an intermediate pose of my task has the following discontinuity of residue number.
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Proper indexing of grafted residues by CCDEndsGraftMover
Submitted by cttm4a1 on Wed, 2022-09-07 23:41
Category:
Design
I found that the grafted residues by CCDEndsGraftMover do not have proper indexing. They have no chain ID, and all residue numbers are 0. If the XML option copy_pdbinfo was set to 1, the grafted residues just shared the same chain ID and residue number as the original segment. I am wondering if there are any movers that do the following tasks.
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Sequence symmetry during FastDesign for repeat protein design
Submitted by cttm4a1 on Tue, 2022-09-06 21:02
Category:
Design
I want to design a repeat protein that self-assembles into a designed structure. As a result, I want each repeat to acquire the same sequence after the FastDesign mover. Is it possible that during FastDesign mover, all repeats are mutated the same way? Is there any Taskoperation (or mover) I can call to set up such a constraint?
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Get fasta from PDB script correction - Solved
Submitted by ialvy on Tue, 2022-08-30 00:00
Category:
Design
Dear researchers,
Those who really want to use the get_fasta_from_pdb.py script to generate the FASTA files from PDB, generally face some sorts of errors.
The most common error is: TabError: inconsistent use of tabs and spaces in indentation
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Designing Feasible Backbones
Submitted by csvajda on Sat, 2022-08-13 08:08
Category:
Design
Enzyme Design
Loop Modeling
Hi there!
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