InterfaceAnalyzer manual refers to RosettaHoles (version 1, ProteinSci2009) for details about the metric
packstat. But is the RosettaHoles score calculated by InterfaceAnalyzer only for the interface, or for the whole complex? (Current holes application is version 2, thus can not test it myself.) If it is calculated only using the interface residues, could it include the voids not at the interface by accident (voids formed by interface residue side chains otherwise would have been filled by residue not included in the calculation)?