I'm beginning to play around with CoupledMoves for flexible backbone design and I am unable to get it to alter the protein backbone coniguration.
When I run the tutorial here (https://github.com/Kortemme-Lab/coupled_moves-tutorial) it works. But when I try and apply that (or similar) command to another protein it will deisgn the sequence, but all the output pdbs have no coordinate changes.
I have tried to simplify the comand line to the barest/most default possible, but I still cant get it to work. I suspect I'm doing something dumb, but can't figure out what exactly. Any guidance would be apprecaited.
Command and resfile below:
~/Rosetta/rosetta_bin_mac_2020.08.61146_bundle/main/source/bin/coupled_moves.static.macosclangrelease -ex1 -ex2 -extrachi_cutoff 0 -mute protocols.backrub.BackrubMover -nstruct 4 -coupled_moves::ntrials 20 -s 2ilk.pdb -resfile test.resfile
1 - 6 A ALLAAxc