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How do I change the default Compiler for Rosetta?

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How do I change the default Compiler for Rosetta?

Hello Rosetta users,


I have a few questions with respect to antibody modelling in Rosetta.


The current version of Rosetta I'm using is a pre-compiled version 3.13 of Linux.  I always get an error when I perform the first step of Antibody Modeling:  

antibody.static.linuxgccrelease \

    -fasta antibody_chains.fasta


I checked and found that the solution to this problem was to install a higher version of GCC.  

But after I installed a higher version of GCC=11.2.0, this error persisted no matter how much I changed my environment variables.  

And I see in the "ROSETTA_CRASH.log" file:  

    [COMPILER]: GCC version "4.8.5 20150623 (Red Hat 4.8.5-39)"  


This means that my Compiler has never been successfully changed.  


I would like to ask how can I change the compiler called by the Rosetta?  Is there a config file to control the compiler version?

Post Situation: 
Wed, 2022-03-16 00:23


Scons throws away all the enviorment varibles by default. 

You can edit `main/source/tools/build/site.settings` to add overides. If this file does not exist, type cp tools/build/user.settings.template tools/build/user.settings, then proceed to edit it.


"overrides" : {
"cc" : "<C compiler command>",
"cxx" : "<C++ compiler command>",


or you can also import your enviorment

– Uncomment (i.e. remove the pound sign from) the import os line.
– Uncomment the program_path“ : os.environ[“PATH”].split(”:“), line.
– Uncomment the “ENV” : os.environ, line.

If the line “ENV” : os.environ, does not exist, add it to the “overrides” section:

"overrides" : {
    "ENV" : os.environ,



More info here:

Good luck!

Wed, 2022-03-16 01:53

Thank you so much for your help, Ajasja  
I solved the problem in a different way.  
I used a pre-compiled version of Rosetta when the C++ version problem occurred.  
I downloaded the source code, compiled and installed it using a higher version of c++ (8.1.3), and the problem disappeared, even though the c++ version in my current environment is 4.8.5.  

So, I think Rosetta may have built some C++ code into it when it was compiled, and it may execute independently of the C++ version in the environment.  
Based on this information, I suspect that the pre-compiled version of "Rosetta 3.13 source + binaries for Linux" on the website may be problematic, at least for this step of antibody homology modeling not working properly.  

Thu, 2022-03-24 22:39