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Changing amino acid profile while keeping the backbone conformation between 2 protein structures (need help)

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Changing amino acid profile while keeping the backbone conformation between 2 protein structures (need help)
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Hello, i am a masters student trying to play around with rosetta. And i have a project in mind. I have two protein structures: nanocages. each with 60 monomers but the chains are a little bit different with different aa profiles. Now what I want to do is to make a structure with the backbone conformation profile of one of the nanocages but with the amino acid profile of the other one. How do i go about doing this? I'm sorry if I wasn't clear english is not my native language. 

Thanks for your help in advance. 

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Wed, 2023-05-24 07:46
seamoon