I know that Rosetta's energies are given in Rosetta Energy Units (REU), which are not real free energy units, but which sometimes correlate linearly with real free energies.
This means that if I have a bunch of dGs given by Rosetta, I compare them and interpret these values as Rosetta's telling me that this process is more favorable than this other process, and so on.
I am wondering about the interpretation of a single, isolated, value of dG given by Rosetta. For example, when Rosetta outputs a negative dG, can I interpret this as Rosetta's telling me that this is a favorable process? Or is a single, isolated, dG value meaningless, which acquires meaning only when it is compared with other dG values given by Rosetta?