This protocol will simply do low-resolution followed by high-resolution docking.
It will also report the binding energy (ddg) and buried-surface area (sasa) in the score file.
<ROSETTASCRIPTS>
	<SCOREFXNS>
		<ligand_soft_rep weights=ligand_soft_rep>
			<Reweight scoretype=hack_elec weight=0.42/>
			<Reweight scoretype=hbond_bb_sc weight=1.3/>
			<Reweight scoretype=hbond_sc weight=1.3/>
			<Reweight scoretype=rama weight=0.2/>
		</ligand_soft_rep>
		<hard_rep weights=ligand>
			<Reweight scoretype=fa_intra_rep weight=0.004/>
			<Reweight scoretype=hack_elec weight=0.42/>
			<Reweight scoretype=hbond_bb_sc weight=1.3/>
			<Reweight scoretype=hbond_sc weight=1.3/>
			<Reweight scoretype=rama weight=0.2/>
		</hard_rep>
	</SCOREFXNS>
	<LIGAND_AREAS>
		<docking_sidechain chain=A cutoff=6.0 add_nbr_radius=true all_atom_mode=true minimize_ligand=10/>
		<final_sidechain chain=A cutoff=6.0 add_nbr_radius=true all_atom_mode=true/>
		<final_backbone chain=A cutoff=7.0 add_nbr_radius=false all_atom_mode=true Calpha_restraints=0.3/>
	</LIGAND_AREAS>
	<INTERFACE_BUILDERS>
		<side_chain_for_docking ligand_areas=docking_sidechain/>
		<side_chain_for_final ligand_areas=final_sidechain/>
		<backbone ligand_areas=final_backbone extension_window=3/>
	</INTERFACE_BUILDERS>
	<MOVEMAP_BUILDERS>
		<docking sc_interface=side_chain_for_docking minimize_water=true/>
		<final sc_interface=side_chain_for_final bb_interface=backbone minimize_water=true/>
	</MOVEMAP_BUILDERS>
	<MOVERS>
	single movers		
		<StartFrom name=start_from chain=A>
			<Coordinates x=25.97 y=0.476 z=-12.77/>
		</StartFrom>
		<Translate name=translate chain=A distribution=gaussian angstroms=3 cycles=50/> first place the ligand
                <Rotate name=rotate chain=A distribution=gaussian degrees=360 cycles=800/>
                <SlideTogether name=slide_together chains=A/>
                <HighResDocker name=high_res_docker cycles=6 repack_every_Nth=3 scorefxn=ligand_soft_rep movemap_builder=docking/>
                <FinalMinimizer name=final scorefxn=hard_rep movemap_builder=final/>
                <InterfaceScoreCalculator name=add_scores chains=A scorefxn=hard_rep/>		
	compound movers
		<ParsedProtocol name=low_res_dock>
			<Add mover_name=start_from/>
			<Add mover_name=compound_translate/>
			<Add mover_name=rotate/>
			<Add mover_name=slide_together/>
		</ParsedProtocol>
		<ParsedProtocol name=high_res_dock>
			<Add mover_name=high_res_docker/>
			<Add mover_name=final/>
		</ParsedProtocol>
	</MOVERS>
	<PROTOCOLS>
		<Add mover_name=low_res_dock/>
	  <Add mover_name=high_res_dock/>
		<Add mover_name=add_scores/>
	</PROTOCOLS>
</ROSETTASCRIPTS>