AtomWorks & RosettaFold3 (in ModelForge) now open-source on GitHub

We’re excited to share that two major repositories are live on the RosettaCommons GitHub: AtomWorks and ModelForge. 

AtomWorks is a broadly applicable data framework for manipulating structural data and developing biomolecular foundation models across a wide range of biological tasks. AtomWorks has already been used to train structure prediction, generative protein design, and fixed-backbone sequence design models. Learn more about how AtomWorks was used to train RosettaFold-3 (RF3) in the recent preprint, “Accelerating Biomolecular Modeling with AtomWorks and RF3”.

RF3, the leading open-source structure prediction method, has been released in the new  ModelForge repository. ModelForge will serve as a central location for many models (including all models from the IPD) in the future to avoid integration overhead. RF3 is the first to be released in ModelForge, but there will be more to come soon! 

Under Construction!
AtomWorks and RF3 developers are working with the Rosetta Commons Devel Team (Hope Woods, Rachel Clune, Sergey Lyskov, and Rocco Moretti) to make these tools easier to use and contribute to (clearer docs, simpler setup, friendlier contribution guides).

We’ll keep the community updated as both repos evolve. In the meantime, feel free to explore these and see how they can be used in your research! 

If you have any questions, comments, or concerns post on Slack or reach out to the Rosetta Commons team via our Contact Form.