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Designing antibodies that bind a specific epitope normally requires immunization or screening millions of variants. Traditional workflows take months and often miss therapeutically relevant binding…

The Institute for Protein Design (IPD) at the University of Washington has announced new leadership updates. Neil King, an Associate Professor in the Department of…

RFDpoly is a generative diffusion framework for the design of de novo biopolymers such as DNA, RNA, proteins, and mixed assemblies. Building on RFdiffusion, it…

Two talks from our community — one by César Ramírez‑Sarmiento and one by Chris Bahl — are now live on the TED platform. 1. César…

We’re excited to share that Tanja Kortemme has received a major NIH award for her project “De novo design and engineering of biological error correction.”…

We are pleased to share the results of the recent Rosetta Commons Executive Board election for the 2025–2027 term. Thank you to everyone in the…

Researchers at Qian Cong’s Lab have released RoseTTAFold2-PPI, a deep-learning model designed to predict how proteins interact with each other. Built on the RoseTTAFold2 architecture,…

Can we make complex protein machines from scratch? We used Rossetta to design a random protein walker that moves along a designed protein track. For…

In biology, timing is everything. From a neuron firing at the right moment to an immune signal fading at just the right pace, the speed…