Latest News
Using protein design experiments to guide energy-function development
Why this matters When a protein is designed on a computer, tiny “impossible overlaps” between atoms can slip into the model. Those clashes may look…
Rosetta Commons postdoc info sessions happening soon
The JEDI committee is hosting a two-part virtual info session spotlighting postdoctoral opportunities across the Rosetta Commons. Interested PIs will give short, focused overviews of…
Protein design workflows series kick off with Protflow and Ovo
On January 20, the protein design community kicked off a new Protein Design Workflows meeting series focused on how people are building, running, and scaling…
Optimizing Stability in Dynamic Small-Molecule Binding Proteins
Why this research matters Many proteins must change shape to function. For proteins that bind small molecules, this motion is essential for activity but often…
Tech Tea Time – New Community Meeting series
Our first TechTeaTime, a new community meeting series event, happened on January 26, with 46 people joining. Rafi Brent (Baker Lab, University of Washington) gave…
Quarterly PyRosetta builds now available
We are happy to announce the availability of quarterly PyRosetta builds. These builds provide persistent wheel packages that are retained long-term (potentially indefinitely), making it…
Stable de novo protein design via joint conformational landscape and sequence optimization
Why this research matters Protein design only works if a designed sequence reliably folds into the intended structure. In practice, many designs that look promising…
Designing new enzymes around catalytic arrays with Riff-Diff
Markus Braun, Adrian Tripp, and colleagues from the Oberdorfer lab at Graz University of Technology developed Riff-Diff, a computational pipeline that designs enzymes by scaffolding…
RFdiffusion3 is Now Available in foundry
The RFdiffusion3 (RFD3) training and inference code is now available through foundry. This third-generation model builds on RFdiffusion1 and RFdiffusion2, expanding the scope of what…