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application for affinity optimization

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application for affinity optimization


Which application is suited for increasing affinity between 2 proteins? I would like to specify ranges of residues to be mutated in only 1 of the proteins/chains, e.g. in a resfile. 

Essentially I want to do something like the opt-dG application in RAbD, but with ranges of residues a protein domain that is not an antibody. Can the opt-dG do this?

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Fri, 2020-03-13 03:24