I'd like to change the rosetta scoring function in remodel to favour models that have less hydrophobic area. Main reason is low computing power for the task at hand.
Changing fa_sol is definitely the option? Should i change the lk_ball_wtd as well?
Second thing is the assignment of secondary structure. I have clear helix propensity calculations at hand and rosetta seems to put out lots of models with wrong secondary structure even though i assigned H and L in blueprint per calculations. Should i reduce the rama_prepro or smth else?
Thanks for your time!