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industrial example of ROSETTA modeled protein

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industrial example of ROSETTA modeled protein

This is a general question,

Is there any example of proteins modeled by ROSETTA  which is currently being used in industry, whether it is enzymes or therapeutics or any other biomolecules? 


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Sat, 2016-04-23 23:40

Industry plays its cards close to the vest so we don't know what they've actually used Rosetta for.  It's also true that they'd use Rosetta as a part of a long pipeline, with many other tools used along the way.

The Kuhlman lab developed a bispecific antibody technology in collaboration with Eli Lilly.  (  I assume Lilly is finding it useful, and there is a spinoff company which is commercializing it as well.

Arzeda ( offers enzyme design, they certainly started using Rosetta, and I assume they are using it now; probably many of their products have had Rosetta's hand in it.

Why do you need to know?  


Sun, 2016-04-24 08:05

I was giving a talk with explanation of computational protein modeling in some slides and was asked the question. I included application examples from publications but didnt know of an actual example where molecules modeled with ROSETTA have been used to produce or is an ingredient of products used everyday.  I tried to search the web but as you mentioned its probably confidential info so I couldnt find anything interesting. if you know of anyother examples, whether ROSETTA or other computational modeling softwares, any comments will be appreciated. thanks for your reply.

Sun, 2016-04-24 20:10

Here's another on the antibody thread that Andrew passed along:


Here's two more from Florian:


There is also this paper

though I don't know if the obtained enzyme is really used in an industrial process.


the enzyme here

has been patented, but I don't know if anyone has licensed the patent and/or is marketing the enzyme


Mon, 2016-04-25 08:05

Also, cryptically, "and I guess kumamax is also a very good example" - I know nothing more there than google.

Mon, 2016-04-25 08:07

thanks steven. :)

Tue, 2016-04-26 00:47