RFD3 Tutorials Are Here!
We’re excited to announce that three introductory tutorials for RFdiffusion3 (RFD3) are now available in the Foundry documentation! Whether you’re just starting with RFD3 or looking to refine your design workflows, these tutorials guide you step-by-step through creating new protein structures for your design projects.
What’s covered?
Each tutorial focuses on a common design challenge:
- Enzyme binder design: Learn how to design a scaffold around an enzyme active site for a given ligand.
- Protein-protein interface design: Explore the settings involved in designing proteins to interact with a given input protein.
- Nucleic acid binder design: Learn how to use unindexed motifs and hydrogen-bonding constraints to create proteins that bind to nucleic-acid structures.
These tutorials were developed in collaboration with the researchers who built RFD3, ensuring that you’re learning the recommended best practices from the experts themselves. Each tutorial revolves around a practical example, includes images to help visualize the process, and provides example input and output files so you can check your own attempts.
Dive in: You can explore the full RFD3 documentation here.
Get involved: Foundry is open-source! You can contribute by improving the documentation or adding your own examples. Open a Pull Request or Issue, start a Discussion, or reach out directly to Rachel Clune, the Rosetta Commons Documentation Writer, with any questions or feedback.