Community Newsletter
May 2026 - 20th Edition
Catch-Up With Jeff
Where in the world did Jeff visit? Keep reading to find out!
On the last weekend in April, the Rosetta Commons Executive Board gathered for a retreat in Toronto, Canada. Focused on strategic planning for the future of Rosetta Commons, the retreat was dynamic and productive; we look forward to sharing more information with you all soon. Mostly we plugged away in our conference room, but we did get to experience some wonderful food in Toronto, we saw Lake Ontario on our walk to a restaurant, and a few of us hit the CN Tower (world’s tallest free-standing structure for 32 years!) before catching our flights home.
With May comes graduation for many students in labs in our community. I want to extend my congratulations to the Class of 2026 for all of their hard work and exciting research. I look forward to seeing what you all accomplish as you progress in your career.
Now that Summer RosettaCon registration has closed, I want to highlight three upcoming regional gatherings intended to expand collaborations and innovations in our community. Registration is currently open for European RosettaCon (Lisbon, Portugal), the 2nd Symposium on Protein Design and Engineering (Campinas, Brazil, RC is a co-sponsor), and for the first time RosettaCon Asia (Beijing, China). I will be attending RosettaCon Asia and look forward to connecting with the attendees throughout the event. Thank you to all our members who are hard at work organizing these conferences for the community.
Cheers,
Jeff
Latest News
A Zero-Shot Approach to de novo Metalloenzyme Design
In a new study published on bioRxiv, researchers from Stanford University and EPFL introduce dEVA (design by EVolutionary Algorithm), a framework that achieved the zero-shot design of a highly efficient metalloenzyme without any reliance on natural templates.
Speed Up PyRosetta Development with Autocompletion and Type Checking
PyRosetta now comes packaged with type stub files (.pyi). Type stub files can be used by the Integrated Development Environment (IDE) of your choosing to improve code autocompletion and type analysis for a more streamlined development experience.
Summer 2026 Workshop Registrations Now Open
Two exciting week-long workshops this summer are now accepting applications: ML & Rosetta Into Bootcamp July 20 - 24 at John Hopkins University and Leipzig Rosetta Workshop August 17 - 21 at Leipzig University.
Upcoming Events
European RosettaCon 2026
Early Bird Registration Closes May 31
Theme: Crossing Boundaries with Protein Design
Dates: October 28 - 30, 2026
Location: Universidade Nova de Lisboa, Lisbon, Portugal
2nd Symposium on Protein Design and Engineering
Registration Closes June 15
Topic: AI for Protein Design
Dates: October 5 - 8, 2026
Location: CNPEM, Campinas, Brazil
Co-sponsored by Rosetta Commons
RosettaCon Asia 2026
Abstracts Due by June 15
Registration Closes July 15
Theme: The Present and Future of Protein Design
Dates: October 10 - 11, 2026
Location: Peking University, Beijing, China
Membership Spotlight
Anum Glasgow, Ph.D.
Assistant Professor
Glasgow Lab, Columbia University Medical Center
Scientific Endeavors
“I’ve been wondering how millions of protein functions could arise from just a few thousand protein folds found in nature,” said Anum. To understand this better, her group applied high-resolution HX-MS to compare the “energetic blueprints” of two protein families that share the same fold. This shared set of inter-residue relationships is conserved in different ways in different protein families, even when all the proteins look similar. They used the energetic blueprint to rationally engineer ligand sensitivity in a transcription factor. The pre-print paper is available now and will be published soon in Nature Chemistry.
“This application is something I completely failed at in my postdoc, because I didn’t know the protein family secret yet.”
About Anum
Anum started as an undergraduate researcher in David Gracias’ lab as she completed her BS in biomedical engineering at Johns Hopkins University. She then switched from materials chemistry to molecular biology in grad school while at UC Berkeley, where she worked in Danielle Tullman Ercek’s lab to engineer a protein secretion system. With a growing interest in more rational approaches to protein engineering, she joined Tanja Kortemme’s lab at UCSF as a postdoc to learn how to design proteins computationally. After six awesome years there engineering biosensors and therapeutics, she became obsessed with protein allostery, the focus of her lab at Columbia University. Outside of research, Anum spends her days hanging out with her husband and baby as she continues to grow in her new role as mom.
“Ask lots of questions to tap into the collective wisdom of our community. You’ll add to it yourself soon.”
Rosetta Community
The Rosetta Commons maintains world-class training opportunities, including the internship program for undergraduates, the RaMP program for post-bacs, and educational workshops and bootcamps year-round. It is really fun to see students start out as interns or post-bacs and then remain in the Rosetta community to become master protein designers, or leave for another field to do amazing work there.
Announcements
Rosetta Commons Website Update:
Software & Tools Download & Support Pages
We want to highlight a recent update to our Rosetta Commons website. We have combined the download, documentation, getting help, and user support pages into a new Download & Support page. It includes new software and tools not previously listed on our website and is complimented by a new User & Developer Resources page. Big thank you to Rachel Clune, Hope Woods, and Julia Koehler Leman, for their help organizing, sorting, and content curating the information on these pages.
Rosetta Commons Jobs
Check out our Jobs board for the latest postings.
Newsletter Archive
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