Hi,
I hope you are having a nice weekend. I used the InterfaceAnalyzerMover using the interface option to calculate the change in free energy between chain A being bound or unbound to chains B and C. I then also calculated the binding affinity in the same way between chain B and chains A and C, and chain C and chains A and B. Can I take the mean of the three binding affinities I calculated to represent the binding affinity holding the trimer together? Can I compare the mean binding affinity of different trimers to one another using the same scoring function?
Thank you,
Franz
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