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Rigidifying ligand

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Rigidifying ligand

I have a ligand with which I am trying to design a pocket in a synthetic protein.

Now the ligand doesn't have any rotatble bonds, because it's carbon chain is full of conjugated bonds,

However it keeps isomerizing some of the bonds,

is there any way I could completly fix the carbon chain?

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Sun, 2024-02-18 12:10