I use Rosetta 3.5 to perform SymDock using D8 symmetry and got most docking decoys of the following scores:
SCORE: score fa_atr fa_rep fa_sol fa_elec fa_pair hbond_sr_bb hbond_lr_bb hbond_bb_sc hbond_sc dslf_ss_dst dslf_cs_ang dslf_ss_dih dslf_ca_dih atom_pair_constraint fa_dun I_sc cen_rms rms st_rmsd maxsub time description
SCORE: 781.142 -6075.987 209.017 2592.860 -53.066 -77.647 -235.804 -163.348 -93.127 -83.263 4189.354 46.876 99.084 2.994 218.498 204.702 -273568608.403 0.000 0.000 0.000 234.000 1172.000 MNMR_input_0001
the I_sc values seems to be too good. It is also amazing that the total score is still positive with such good I_sc scores. I relaxed the unit before doing symmetric docking. No obvious clashes are observed while inspecting the docking results. What could be the reason for the I_sc values?