Latest News
Announcing the 2025–2027 Rosetta Commons Executive Board
We are pleased to share the results of the recent Rosetta Commons Executive Board election for the 2025–2027 term. Thank you to everyone in the…
RoseTTAFold2-PPI: Predicting Protein Interactions with AI
Researchers at Qian Cong’s Lab have released RoseTTAFold2-PPI, a deep-learning model designed to predict how proteins interact with each other. Built on the RoseTTAFold2 architecture,…
De-novo design of a random protein walker
Can we make complex protein machines from scratch? We used Rossetta to design a random protein walker that moves along a designed protein track. For…
Designing proteins that know when to let go
In biology, timing is everything. From a neuron firing at the right moment to an immune signal fading at just the right pace, the speed…
A new generation of vaccines: Combining design and delivery
In the wake of the COVID-19 pandemic, two vaccine technologies stood out – mRNA vaccines like those from Pfizer and Moderna, and protein nanoparticle vaccines…
Rosetta + Cursor: Simplifying Protein Design with AI Assistance
The Rosetta MCP Server project, created by Ariel J. Ben-Sasson, is a powerful tool that will make it easier to use Rosetta, RosettaScripts, and PyRosetta…
One-shot design of functional protein binders with BindCraft
Read more: https://www.nature.com/articles/s41586-025-09429-6 Authors: Martin Pacesa, Lennart Nickel, Christian Schellhaas, Joseph Schmidt, Ekaterina Pyatova, Lucas Kissling, Patrick Barendse, Jagrity Choudhury, Srajan Kapoor, Ana Alcaraz-Serna, Yehlin…
Roland Dunbrack Receives ASBMB DeLano Award
Rosetta Commons is delighted to celebrate Roland L. Dunbrack, Jr., recipient of the ASBMB DeLano Award for Computational Biosciences. This award honors scientists whose computational…
Summer RosettaCon 2025 Recap
From August 4 to 8, 2025, the Rosetta community gathered at Suncadia Resort near Seattle, Washington, for Summer RosettaCon 2025. The conference hosted 313 in-person…