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Why this research matters Protein design only works if a designed sequence reliably folds into the intended structure. In practice, many designs that look promising on a computer fail when tested in the lab. This study takes a direct, experimental approach to a simple question: which current protein design strategies actually produce stable proteins? Background:…

Markus Braun, Adrian Tripp, and colleagues from the Oberdorfer lab at Graz University of Technology developed Riff-Diff, a computational pipeline that designs enzymes by scaffolding protein backbones around catalytic residue arrays. Read the full paper in Nature paper here.  Why this research matters Designing enzymes from scratch could help tackle unmet needs in biocatalysis, therapeutics,…

Designing antibodies that bind a specific epitope normally requires immunization or screening millions of variants. Traditional workflows take months and often miss therapeutically relevant binding sites. A new study shows that it is now possible to generate antibody candidates entirely on a computer, then confirm their structures experimentally, including at atomic resolution. Background Current antibody…

RFDpoly is a generative diffusion framework for the design of de novo biopolymers such as DNA, RNA, proteins, and mixed assemblies. Building on RFdiffusion, it extends the method beyond proteins by enabling the generation of backbones containing sugar and phosphate moieties to allow for the design of DNA and RNA structures. In the original RFdiffusion…