Learning Hub
ML Protein Design Bootcamp Now Available on YouTube
Hosted in November 2025 by the University of California Davis, this course provides a practical, beginner-friendly overview of modern AI/ML tools for protein structure prediction and design, including AlphaFold, ESMFold, ProteinMPNN, and RFdiffusion, along with the workflows that connect them. This is a relatively novice-level course. The curriculum is focused on understanding and using existing…
Read MoreRFD3 Tutorials Are Here!
We’re excited to announce that three introductory tutorials for RFdiffusion3 (RFD3) are now available in the Foundry documentation! Whether you’re just starting with RFD3 or looking to refine your design workflows, these tutorials guide you step-by-step through creating new protein structures for your design projects. What’s covered? Each tutorial focuses on a common design challenge:…
Read MoreDocumentation Playbook Now Available
The Documentation Playbook is a new guide designed to make writing and maintaining documentation for your software projects clearer and easier. The Documentation Playbook is part of the Playbooks Project from the Open Molecular Software Foundation (OMSF). What’s inside: An overview of the different types of documentation that are useful for open-source scientific software projects…
Read MoreTwo Rosetta community talks now live on TED
Two talks from our community — one by César Ramírez‑Sarmiento and one by Chris Bahl — are now live on the TED platform. 1. César Ramírez‑Sarmiento — “The new era of AI-powered protein design” In his talk, César Ramírez-Sarmiento, a 2025 TED Fellow and protein engineer, explores how artificial intelligence is rewriting the rules of…
Read MoreRosetta + Cursor: Simplifying Protein Design with AI Assistance
The Rosetta MCP Server project, created by Ariel J. Ben-Sasson, is a powerful tool that will make it easier to use Rosetta, RosettaScripts, and PyRosetta in your protein design projects. It allows tools like Cursor – an AI-powered coding assistant that integrates with common code editors – to directly interact with the Rosetta/PyRosetta software to…
Read MoreIntroducing Foldit Education Mode v2 on the Web
In 2020, as the pandemic set in and classes moved online, the Foldit team realized we had a tremendous opportunity to help the science education community that was desperate for good science learning tools. We therefore created and released Foldit Education Mode in August 2020 as a ready-made teaching tool for biochemistry that instructors could…
Read MoreNew Bindcraft tutorial now available
BindCraft is a new open-source pipeline for de novo protein binder design developed by Martin Pacesa in collaboration with the Correia Lab (EPFL) and the Ovchinnikov Lab (MIT). Designed to be accessible and efficient, BindCraft was recently released with a detailed tutorial and can be run locally or via Google Colab. The tool enables researchers…
Read MoreRFdiffusion: Beta Documentation Now Available
We’re excited to share that the beta version of the official RFdiffusion documentation is now live! This resource is designed to support users at all levels – from those new to RFdiffusion to experienced researchers looking to get the most out of the tool. Explore the documentation here: https://sites.google.com/omsf.io/rfdiffusion Highlights of the new documentation Help…
Read MoreHow to Improve Psychological Safety in Your Lab
Overview of Psychological Safety Psychological safety was first described over thirty years ago and has been defined as the “shared belief that the team is safe for interpersonal risk taking” (Edmonson, 1999). People of backgrounds historically excluded from STEM are more likely to feel uncomfortable taking risks and sharing their ideas. Thus, psychological safety is…
Read MoreParametric disasters
I recently got a new computer and I have been (slowly) going through my old files to try to maintain a little order around here. So, while I was doing the ol’ twenty-first century upkeep, I stumbled across a file called “nope_nope_nope.mov”. Here’s what was in that file: here’s another one called “strand_fail.mov” that looks…
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