Blog post
Science, Connection, and Community: Summer RosettaCon 2026 Recap
Featured image is a group photo of Summer RosettaCon 2026 in-person attendees. With over 600 in-person and virtual attendees, 56 scientific talks, nearly 200 posters, 16 breakout sessions, 5 keynotes, 4 career panels, 3 tutorials, and countless networking opportunities, Summer RosettaCon 2026 was our largest event to date. Hosted for the first time at the…
Read MoreREU Trainees’ Research Projects Highlight Exciting First Steps in Biomolecular Research
REU trainee Tony Peonio presenting his lightning talk at Summer RosettaCon 2026. This is part three of a three part series about the Rosetta Commons REU experience. How do you remove sargassum blooms impacting coastal marine ecosystems? Can we design an enzyme that breaks down fluorochemicals? How can we reduce chronic pain and inflammation in…
Read MoreA Summer of Science: REU Trainees Conduct Research at Host Labs, Present at Summer RosettaCon 2026
Featured image is the 2026 REU cohort with Program Manager Camille Mathis and PI Jeffrey Gray. This is part two of a three part series about the Rosetta Commons REU experience. Following an intensive week at Code School, Rosetta Commons Research Experience for Undergraduates (REU) trainees departed for an eight-week research experience at host laboratories…
Read MoreCoding, Collaboration, and Camaraderie: REU Trainees’ Introductory Bootcamp 2026
Featured image is of Code School 2026 attendees, including REU trainees, instructors Nate Felbinger and Miranda Simpson, teacher assistants Briana Whitehead, Vani Lorish, and Zhazira Iskakova, and PI Jeffrey Gray. This is part one of a three part series about the Rosetta Commons REU experience. For over a decade, on the first week of June,…
Read MoreTwo-phase computational pipeline yields high-affinity de novo BMP-2 binders for bone regeneration
Key Takeaways By combining Rosetta-based motif grafting with deep-learning tools like RFdiffusion, ProteinMPNN, and AlphaFold2, a two-phase approach successfully generated functional binders where Rosetta-based docking and scoring alone failed. The lead binder, BB5523, demonstrated high affinity and specificity with an apparent KD of 2.07 nM for BMP-2, backed by mutational analysis confirming T42 as a…
Read MoreDe Novo Protein Design Overcomes Gene Editing Limits to Sustain CAR-T and TCR-T Cell Function
Key Takeaways De novo designed proteins bind and modulate entire target families simultaneously, bypassing the translational hurdles of multi-allele gene editing. The OUTLAST Regulator platform employs three distinct functional strategies, Designed Degraders, Transcription Factor Modulators, and Common Substrate Modulators, to rewire complex cell fate decisions. Pan-NR4A OUTLAST Regulators significantly enhance CAR-T and TCR-T cell functional…
Read MoreNew OpenBind-0 model and dataset benchmark co-folding tools in drug discovery
Key Takeaways OpenBind-0 (OB0) is a fully open-source co-folding model built on OpenFold3, trained on Protein Data Bank (PDB) data, and optimized for predicting protein–small-molecule complexes. Alongside the model, a discovery-relevant benchmark dataset of 717 new ligand-bound structures capturing fragment-to-hit progression across FatA and RdRp targets was released. Evaluation across targets shows wide performance variability,…
Read MoreIntegrating Mass Spectrometry Restraints into Rosetta and AlphaFold Modeling Pipelines
Key Takeaways Integrating mass spectrometry data with computational modeling platforms like Rosetta and AlphaFold2 improves the accuracy of protein structure and complex predictions. Experimental data from techniques such as covalent labeling, ion mobility, and surface-induced dissociation help distinguish native-like protein conformations from inaccurate computational outputs. A new set of tutorials and updated PyRosetta implementations make…
Read MoreBrazil’s Largest Open Science Event Introduces Thousands to Protein Design with Foldit
For the second year in a row, Brazil’s largest open science event introduced thousands of children and families to protein modeling and design. The event welcomed around 30,000 visitors from May 29–30, 2026, to the Brazilian Center for Research in Energy and Materials (CNPEM), where they participated in hundreds of scientific activities across various disciplines.…
Read MoreMotivated Trainees and Tutors Shine at FEBS Advanced Practical Course
On April 19-24, 2026, 36 international participants gathered in Blankenberge, Belgium, for the FEBS Advanced Practical Course: Generative AI for Protein Engineering. The course, supported by Rosetta Commons, offered an introduction to protein design, combining theoretical lectures, tool-specific tutorials, and a hands-on project, with a focus on Rosetta Commons tools. Participants were able to work…
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