Latest News
Science & Tools
Two-phase computational pipeline yields high-affinity de novo BMP-2 binders for bone regeneration
Key Takeaways By combining Rosetta-based motif grafting with deep-learning tools like RFdiffusion, ProteinMPNN, and AlphaFold2, a two-phase approach successfully generated…
De Novo Protein Design Overcomes Gene Editing Limits to Sustain CAR-T and TCR-T Cell Function
Key Takeaways De novo designed proteins bind and modulate entire target families simultaneously, bypassing the translational hurdles of multi-allele gene…
New OpenBind-0 model and dataset benchmark co-folding tools in drug discovery
Key Takeaways OpenBind-0 (OB0) is a fully open-source co-folding model built on OpenFold3, trained on Protein Data Bank (PDB) data,…
Documentation & Tutorials
Two Rosetta community talks now live on TED
Two talks from our community — one by César Ramírez‑Sarmiento and one by Chris Bahl — are now live on…
Rosetta + Cursor: Simplifying Protein Design with AI Assistance
The Rosetta MCP Server project, created by Ariel J. Ben-Sasson, is a powerful tool that will make it easier to…
Introducing Foldit Education Mode v2 on the Web
In 2020, as the pandemic set in and classes moved online, the Foldit team realized we had a tremendous opportunity…
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Events
REU Trainees’ Research Projects Highlight Exciting First Steps in Biomolecular Research
REU trainee Tony Peonio presenting his lightning talk at Summer RosettaCon 2026. This is part three of a three part…
A Summer of Science: REU Trainees Conduct Research at Host Labs, Present at Summer RosettaCon 2026
Featured image is the 2026 REU cohort with Program Manager Camille Mathis and PI Jeffrey Gray. This is part two…
Coding, Collaboration, and Camaraderie: REU Trainees’ Introductory Bootcamp 2026
Featured image is of Code School 2026 attendees, including REU trainees, instructors Nate Felbinger and Miranda Simpson, teacher assistants Briana…
Community News
Speed Up PyRosetta Development with Autocompletion and Type Checking
By Harrison Truscott PyRosetta, the Python interface to the Rosetta binary, now comes packaged with type stub files (.pyi). These…
Let’s Get Social: New Ways to Connect with @RosettaCommons
Rosetta Commons is a community based on sharing scientific discoveries and fostering collaborations to advance our understanding of protein design…
Rosetta Commons Run (rc-run) Now Available
We are pleased to announce a new Rosetta Commons workflow optimization tool: rc-run. rc-run (invoked as rc) is a command-line…