Latest News
Science & Tools
Two-phase computational pipeline yields high-affinity de novo BMP-2 binders for bone regeneration
Key Takeaways By combining Rosetta-based motif grafting with deep-learning tools like RFdiffusion, ProteinMPNN, and AlphaFold2, a two-phase approach successfully generated…
De Novo Protein Design Overcomes Gene Editing Limits to Sustain CAR-T and TCR-T Cell Function
Key Takeaways De novo designed proteins bind and modulate entire target families simultaneously, bypassing the translational hurdles of multi-allele gene…
New OpenBind-0 model and dataset benchmark co-folding tools in drug discovery
Key Takeaways OpenBind-0 (OB0) is a fully open-source co-folding model built on OpenFold3, trained on Protein Data Bank (PDB) data,…
Documentation & Tutorials
How to Build a Model with AtomWorks: A Step-by-Step Guided Tutorial
Whether you’re training your first machine learning model or your tenth, preparing your data and building the infrastructure around your…
ML Protein Design Bootcamp Now Available on YouTube
Hosted in November 2025 by the University of California Davis, this course provides a practical, beginner-friendly overview of modern AI/ML…
RFD3 Tutorials Are Here!
We’re excited to announce that three introductory tutorials for RFdiffusion3 (RFD3) are now available in the Foundry documentation! Whether you’re…
Events
Science, Connection, and Community: Summer RosettaCon 2026 Recap
Featured image is a group photo of Summer RosettaCon 2026 in-person attendees. With over 600 in-person and virtual attendees, 56…
REU Trainees’ Research Projects Highlight Exciting First Steps in Biomolecular Research
REU trainee Tony Peonio presenting his lightning talk at Summer RosettaCon 2026. This is part three of a three part…
A Summer of Science: REU Trainees Conduct Research at Host Labs, Present at Summer RosettaCon 2026
Featured image is the 2026 REU cohort with Program Manager Camille Mathis and PI Jeffrey Gray. This is part two…
Community News
Announcing the winners of the Winter Protein Design Games 2024: Unleashing Innovation in Enzyme Engineering
The Winter RosettaCon organizers want to thank Liberum Bio for sponsoring the experimental validation of the designs that they carried…
Announcing Rosetta’s Transition to a Public Repository (including Licensing Changes)
Dear Rosetta Community and users of Rosetta, We’re excited to announce that we have moved the Rosetta code repository to…
Future of Rosetta Task Force Update
The FoR Task Force would like to share this update with the Rosetta Commons community. One year ago, at the…